scRNA-Seq of Cdkn2a mutant murine Epithelioid Hemangioendothelioma tumors

Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a TAZ-CAMTA1 fusion in greater than 90% of cases and loss of CDKN2A in human EHE tumors is associated with late stage disease. Murine EHE tumors were created by conditionally expressing TAZ-CAMTA1 and conditionally knocking out Cdkn2a within vascular endothelium. Resultant tumors were used for single cell RNA sequencing and compared against age matched wild type mice tissue. scRNA Sequencing of Cdkn2a mutant Epithelioid Hemangioendothelioma Tumors in Mouse