RNA-seq performed on either wild-type, p53 null, or p21 null MMTV-Wnt1 mouse mammary tumors treated with or without doxorubicin.

The effects of doxorubicin on mammary tumors Overall design: MMTV-Wnt1 transgenic mice formed spontaneous mammary tumors, and then were treated or not with doxorubicin. Genotypes of MMTV-Wnt1 mice were Trp53 wild-type (untreated n=6, doxorubicin n=6), Trp53 null (untreated n=6, doxorubicin n=6), Cdkn1a (p21) null (untreated n=6, doxorubicin n=10). Tumors were harvested 24hr following final doxorubicin treatment.