Catalytic Copper-Mediated Ring Opening and Functionalization of Benzoxazoles
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Catalytic_Copper_Mediated_Ring_Opening_and_Functionalization_of_Benzoxazoles/2237476
下载链接
链接失效反馈官方服务：
资源简介：
A novel
reaction involving benzoxazole, ethyl diazoacetate, and
water has been discovered, with TpBr3Cu(NCMe) (TpBr3 = hydrotris(3,4,5-tribromopyrazolyl)borate) as the catalyst. The
fused azoles are converted into highly functionalized substituted
benzenes bearing aldehyde, amine carboxylate and hydroxyl groups.
The protocol has been applied for a series of benzoxazoles with several
diazo compounds. Experimental data and theoretical calculations have
led to a mechanistic proposal that includes carbene addition, ylide
formation, and water addition to the latter, all those steps being
catalyzed by the copper center.
创建时间：
2016-02-16
