CASP9 is phosphorylated at T412

Phosphorylation of caspase 9 (CASP9) may contribute to the suppression of apoptosis. A major inhibitory phosphorylation site in CASP9 is Thr412, which forms part of a Thr‑Pro motif (Allan LA & Clarke PR 2007; Martin MC et al. 2008). This motif is targeted by multiple proline‑directed kinases such as ERK1/2 in response to extracellular growth/survival signals or CDK1‑cyclin B1 during mitosis (Allan LA et al. 2003; Allan LA & Clarke PR 2007; Martin MC et al. 2008). Thr412 is also phosphorylated by DYRK1A, which regulates apoptosis during development (Seifert A et al. 2008).

Caspase 9（CASP9）的磷酸化作用可能对凋亡的抑制起到一定作用。CASP9中的主要抑制性磷酸化位点为Thr412，该位点构成Thr-Pro基序的一部分（Allan LA & Clarke PR 2007；Martin MC 等人，2008）。该基序成为多种脯氨酸导向激酶的作用靶点，例如ERK1/2，这些激酶在响应细胞外生长/存活信号或CDK1-细胞周期蛋白B1于有丝分裂期间被激活（Allan LA 等人，2003；Allan LA & Clarke PR 2007；Martin MC 等人，2008）。Thr412亦被DYRK1A磷酸化，而DYRK1A在发育过程中调节凋亡（Seifert A 等人，2008）。