Figure S1 - Role of Humoral versus Cellular Responses Induced by a Protective Dengue Vaccine Candidate

AG129 mice were immunized with 1×106 DENV2 E85-DENV2 E85-VRP i.p. 14 and 5 days prior to challenge with 5×108 GE DENV. Some groups were depleted of their CD4+ or CD8+ T cell populations as indicated. Baseline and ADE groups were included. Three days after challenge, levels of TNF (A), IFN-γ (B), IL-1β (C) and KC (D) were measured in the serum. Each symbol depicts one mouse, P-values from two-tailed unpaired t-test with Welch's correction, confidence interval 95%, * P≤0.05, ** P≤0.01, *** P≤0.001.
(EPS)