Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

Sulfonyl hydrazones were synthesized
by one-pot reaction using
sulfonyl chlorides, hydrazine hydrate and aldehydes under mild, cheap
and environmental safe conditions. The optimized reaction afforded
nine products with yields higher than 94% and four products with yields
between 34% and 83%. Also, this paper reports, for the first time,
the reduction of hydrazine amount (1.2 equiv) in sulfonyl hydrazones
synthesis, presenting an excellent perspective to the sustainable
production of new drug candidates.