Access to Amino Lactones through Palladium-Catalyzed Oxyamination with Aromatic Amines as the Nitrogen Source

Although the synthesis of amino lactones with various
nitrogen
sources has achieved great success, variants focused on aromatic amine
counterparts still remain elusive. Herein, we communicate the intermolecular
oxyamination reaction of aromatic amines and unactivated alkenyl carbonyl
compounds under palladium catalysis. In the reaction, both primary
and second aromatic amines yield the corresponding β-arylamino-γ-lactones
efficiently. A key step in this process involves a PdII/PdIV catalytic cycle incorporating a 1,2-(C–N)/(C–O)
dyotropic rearrangement. This reaction demonstrates mild reaction
conditions and good functional group compatibility.