GNPS - Obesity and GDM associated changes in placental and maternal blood lipidomic profile: evidence for sexual dimorphism

This study assesses fatty acid composition of lipids in matched maternal plasma and placental tissue from lean, obese and gestational diabetes (GDM) women stratified by fetal sex. Obesity and GDM are associated with adverse pregnancy outcomes and program the offspring for cardiometabolic disease in a sexually dimorphic manner. We collected maternal plasma and placental villous tissue following elective cesarean section at term from women who were lean (pre-pregnancy BMI 18.5-24.9), Obese (BMI>30) and type A2 GDM (matched to obese BMI) with either a male or female fetus (n=4 each group). Lipids were extracted and fatty acid composition of different lipid classes were analyzed by LC-MS/MS to find significant changes in GDM vs Obese, GDM vs Lean, and Obese vs Lean.