Additional file 5 of Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women

Table S1. The 22 identified CpGs selected by our weighted Lasso with data integration, together with their annotation. The first columns give the corresponding gene symbol and Illumina ID. Next follows the estimated regression coefficient β ̂ $\hat {\boldsymbol {\beta }} $ from the optimal fitted model. The locations are described by CHR (chromosome) and Mapinfo (base pair position on the chromosome). The annotations are described by Probe SNPs (single nucleotide polymorphisms) Probe SNPs 10 (one SNP within 10 base pairs of the CpG site), Ucsc refgene group (see Additional file 1: Figure S5 for more details). Relation to ucsc CpG island (where the label Island is a region with high frequency of CpG sites, N Shore or S Shore are neighboring region 5’ or 3’ to CpG island, N Shelf or S Shelf are neighboring region 5’ or 3’ to CpG shore), DMR (differentially methylated regions), Enhancer (region of DNA that binds proteins to regulate transcription of a gene), Regulatory feature group (Promoter Associated or unclassified) and DHS (DNase I hypersensitive sites are regions where the chromatin has lost its condensed structure, exposing the DNA and making it extra accessible to DNAse cleavage). No mark means no available information. Information is taken from Illumina. (XLSX 48 kb)