Pharmacokinetics parameters of cardiotoxin following intravenous and intramuscular administration of whole Naja sumatrana venom into rabbits.

The sub-lethal dose of N. sumatrana venom injected into rabbits (n = 3, approximately 2 kg each) were i.v.: 0.1 mg/kg and i.m.: 0.5 mg/kg.Data were expressed as mean ± S.D. for n = 3. The pharmacokinetic parameters when only cardiotoxin was injected are taken from Table 4.* AUC0-∞ values were adjusted to the dosage of i.v. injection, i.e. 0.1 mg/kg.