GDF11
收藏rgd.mcw.edu2025-03-23 收录
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=731907
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资源简介:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
本基因编码TGF-β(转化生长因子-β)超家族蛋白的一种分泌型配体。该家族的配体与多种TGF-β受体结合,进而招募和激活SMAD家族转录因子,调控基因表达。编码的前体蛋白经过蛋白酶解加工,生成由二硫键连接的同源二聚体的各个亚基。此蛋白在神经及其他器官系统的发育过程中发挥重要作用,并可能调节衰老过程。 ——(信息提供:RefSeq,2016年8月)
提供机构:
Rat Genome Database



