Significantly associated residues across eleven autoimmune diseases within the peptide-binding groove of HLA-DRB1.

Bold red amino-acids denote independently associated risk signals in the strongest associated DRB1 allele, identified by the authors of each study. Bold green amino-acids denote significant protective signals. SLE: lupus, MS: multiple sclerosis, RA: rheumatoid arthritis, T1D: type 1 diabetes, HT: Hashimoto’s thyroiditis, pSS: primary Sjögren’s syndrome, SSc: systemic sclerosis, UC: ulcerative colitis, CD: Crohn’s disease, PV: pemphigus vulgaris, Vi: vitiligo. *: Complete linkage disequilibrium (D’ = 1).