Genome-wide analysis of hypothalamic gene expression in prenatally undernourished male rat offspring under high fat diet

Based on the developmental origin of health of disease hypothesis, we previously showed that prenatal 70% maternal food restriction (FR30) predisposes the offspring to development of pathologies in adulthood. In the present study, we focused on the hypothalamus gene expression profile of standard and high fat (HF)-fed FR30 adult offspring.基于健康与疾病的发育起源（developmental origin of health of disease）假说，我们既往研究已证实，产前母体70%食物限制（FR30）会使子代在成年期更易发生各类病理病变。本研究聚焦于标准膳食与高脂（HF）喂养的FR30成年子代的下丘脑基因表达谱。