Organocatalytic Domino Entry to an Octahydroacridine Scaffold Bearing Three Contiguous Stereocenters

A facile and enantioselective access
to a functionalized octahydroacridine
scaffold was developed via an organocatalytic domino sequence between
cyclohexenone and 2-N-substituted benzaldehyde. High
levels of yields (up to 99%) and enantioselectivities (up to 99:1
er) were readily achieved in this developed organocatalytic transformation,
which holds promising applications in the construction of complex
multicyclic systems for further pharmacological studies.