Global-scale profiling of differential expressed lysine lactylated proteins in cerebral endothelium of cerebral ischemia-reperfusion injury rats

(i) The lactylation may play a key role in the process of ischemia-reperfusion injury in rats, and may be achieved by regulating Ca2+signaling pathway. (ii) The key proteins of Ca2+ signaling pathway, Scl25a4 (K245), Slc25a5 (K96) and Vdac1 (K20, K266), are modified by lactation, which may affect mitochondrial apoptosis pathway and mediates neuronal death.