FFPE-ATAC decodes the chromatin accessibility from the clinical archived FFPE tissues

We present FFPE-ATAC, a new ATAC-seq tool for chromatin accessibility profiling that decodes the chromatin accessibility from mouse FFPE tissue and clinical archived FFPE tissues. The FFPE-ATAC generates the high-quality chromatin accessibility profiles from clinical FFPE tissue sections with 5-20 µm thickness, and reveals the disease-associated regulatory elements in different types of FFPE archived tissue. FFPE-ATAC enables to decode the chromatin states regulating the gene regulation in the cancer and understand the epigenetic regulation in the translational studies. FFPE-ATAC of mouse liver,cerebellum, and human colonrectal cancer samples. Omni-ATAC of mouse liver sample.