Effect of aging on the global gene expression profiles of mouse olfactory neuroepithelium. Mus musculus

The olfactory system is a part of the mammalian central nervous system and is characterized by neurogenesis and replacement of degenerated neurons. Clinically, it has been reported that the elderly has a high incidence of olfactory impairment. However, the molecular mechanisms underlying aging-associated defect of olfaction have yet been unclear. To elucidate this problem, we performed micoarray analysis against murine olfactory epithelium and compared the transcriptome of them between young-adult and aged mice. Overall design: Gene expression of olfactory epihtelium from young-adult (8 weeks of age) and aged (16 months of age) male C57BL/6 mice was measured. Each total RNA sample pooled from 5 biological replicates (two experimental replicate) was analyzed using microarray.