Structural study of Human endogenous canonical pre-mRNA 3’-end processing complex
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下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-1815343720
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资源简介：
Processing of the 3’-end of precursor messenger RNAs (pre-mRNAs) is a central step in mRNA maturation, which is fundamentalAbstract:
for mRNA stability and translation and, ultimately, for cell viability. Most of pre-mRNAs (canonical mRNAs) are cleaved and polyadenylated by
a large multi-protein complex, the deregulation of which is associated to serious human diseases. Thus, subunits of this RNA processing
machinery are becoming increasingly attractive as drug targets. An example is CPSF3, the endonuclease responsible for pre-mRNAs cleavage
and a promising therapeutic target for the treatment of human cancers (AML, Ewing’s sarcoma). Further investigations of the human
canonical pre-mRNA processing complex as drug target requires a deep knowledge of the molecular mechanism deployed by this machinery,
including its structure and function. Our project aims at grasping this knowledge by unravelling the architecture and mechanisms of the
human endogenous 3’-end pre-mRNA processing complex.
提供机构：
European Synchrotron Radiation Facility
创建时间：
2024-07-12
