Text S1 - Can Non-lytic CD8+ T Cells Drive HIV-1 Escape?

Supplementary Text S1 contains the following: Figure S1. Duration of CD8+ T cell killing has little impact on the observed killing rates. Figure S2. The motility of the simulated CD8+ T cells resembles a random walk. Figure S3. The mean CD8+ T cell speed decreases as the probability of recognition of infected targets increases. Figure S4. For CD8+ T cell operating via a lytic mechanism, the proportion of infected cells at set point decreases as the probability of recognition increases. Figure S5. New infections prevented under a non-lytic CD8+ T cell response that blocks infection. Figure S6. Number of infected CD4+ T cells ‘blocked’ from viral production under a non-lytic CD8+ T cell response that blocks production. Figure S7. Set-point of productively infected cells under a non-lytic CD8+ T cell response that blocks production. Figure S8. New infections prevented under a non-lytic CD8+ T cell response that blocks production. Figure S9. Number of uninfected CD4+ T cells ‘protected’ from infection with increasing effector population size. Figure S10. Immune control exerted by a non-lytic response that reduces infectivity. Figure S11. Immune control exerted by a non-lytic response that reduces virion production. Equivalence of non-lytic models in chronic infection. Supplementary methods.
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