Canine pimary osteosarcoma tissues vs. matched lung metastases. Canine pimary osteosarcoma tissues vs. matched lung metastases

Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Given that cancer genes are conserved among mammals, cross-species genomics of naturally arising cancers opens a powerful approach to identifying oncogenic drivers to broaden the therapeutic opportunities for aggressive cancers. Here, we utilized a dog-to-human cross-species genomics combined with gain- and loss-of-function analysis to uncover novel OS driver genes. Overall design: Eight primary tumor samples compared with matched lung metastases