PROs mean scores and pairwise comparisons in patients with two follow-up visits.

<b>Context: </b>Cushing syndrome (CS) impairs quality of life (QoL) and mood. Prospective real-life data on post-treatment recovery and predictors of improvement are limited. Objectives: Evaluate changes in QoL, depression, and anxiety in patients with CS, before and after biochemical control, and identify predictors of clinically meaningful improvement. <b>Design and Setting</b>: Prospective observational study at a tertiary center. Patients: 68 patients with endogenous CS (60 pituitary, 8 adrenal) were assessed with active disease and again after achieving biochemical control through surgery and/or medication. <b>Outcomes:</b> Patient-reported outcomes included CushingQoL, Beck Depression Inventory-II (BDI-II), and State-Trait Anxiety Inventory (STAI).<b>Table:</b> PROs mean scores and pairwise comparisons in patients with two follow-up visits.