ZNF445 is a primary regulator of genomic imprinting

ZFP445/ZNF445 collaborates with ZFP57 to control genomic imprinting in vivo in mouse and in human embryonic stem cells. We determined that ZNF445/ZFP445, a KZFP that can be traced back to marsupials, binds human and murine ICRs, and together with ZFP57 correctly maintains all but one murine ICR in vivo. Furthermore, the early embryonic expression of human ZNF445 and its intolerance to loss of function mutations in the population suggest a critical role in human development. Study of ZFP445 ChIP-seq in different mouse genomic backgrounds and ZFP57 and KAP1 ChIP-seq in human. All with their respective inputs.