The AP-1/JNK pathway is regulated by CD73 and gets dysregulated in aged hosts leading to defect in anti-pneumococcal function of neutrophils
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We used high through put RNA-sequencing to identify changes in the PMN transcriptome induced by S. pneumoniae infection in order to gain further insight into the signaling pathways that are required for host response and are dysregulated in older individuals. PMNs were isolated from bone marrow of young WT, old WT and CD73KO mice and challenged with S.pneumonia TIGR4 strain in-vitro. Analysis of differentially expressed genes revealed that genes in AP-1/JNK pathway were upregulated in PMNs from CD73KO and old mice but not in PMNs from young mice. Inhibition of AP-1 and JNK using inhibitors boosted the anti-microbial actiivity of neutrophils from old and CD73KO mice.
提供机构：
University at Buffalo
创建时间：
2022-02-20
