Colon Crypt Model 110514 G.nlogo

Computer program that simulates human colon cancer initiation, therapy, and prevention. Chemotherapy of heterogeneous and drug resistant early colon cancers can be simulated. Includes interface, code, and detailed information. Useful for in silico experiments directly from the user interface. Illustrates and plots the cell dynamics of stem cells, transient amplifying cells, and differentiated cells. Data can be saved in spreadsheet format for producing graphs or further analysis. It runs on the open-source multi-platform NetLogo application version 4.1.3 or 5.3.1 available at https://ccl.northwestern.edu/netlogo/index.shtml. Described in the following publication: Bravo R, Axelrod D. A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments. Theoret Biol Med Model. 2013;10:66-89, http://www.tbiomed.com/content/10/1/66. To download the computer program click on the red link “Download file" to the left.