botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane

Synaptic vesicles re-form rapidly after exocytosis, carrying vesicle membrane proteins that had been exposed on the cell surface by exocytosis back into the cell (Sudhoff 2004). The botulinum toxin type B disulfide bonded heavy chain - light chain heterodimer (botB HC:LC dimer) bound to ganglioside GT1b and syntagmin 1 or 2 (SYT) is inferred to be taken up as well, delivering it to the re-formed synaptic vesicle.

神经突触小泡在胞吐作用后迅速重新形成，携带着通过胞吐作用暴露于细胞表面的突触小泡膜蛋白重新进入细胞（Sudhoff 2004）。据此推断，与神经节苷脂GT1b和突触结合蛋白1或2（SYT）结合的肉毒杆菌毒素B型二硫键连接的重链-轻链异二聚体（botB HC:LC dimer）亦被摄取，并将其递送至重新形成的突触小泡。