IBI (Inflammatory Burnout Index)

The Inflammatory Burnout Index (IBI) was developed within the Assiut University IPF Research Program (2022–2026) as a quantitative framework for assessing biological activity and functional reserve in idiopathic pulmonary fibrosis (IPF). IBI operationalizes a structured scoring system derived from longitudinal cohort analysis to characterize dynamic inflammatory–fibrotic balance. The index is designed for research stratification and structured clinical categorization within predefined governance constraints. The model was prospectively locked as Version 1 in March 2024 following internal validation, coefficient freeze, and prespecified analytical closure under the Assiut University IPF Research Program. No recalibration, refitting, coefficient modification, threshold adjustment, or structural alteration is permitted outside a formally declared future version. Any clinical implementation, redistribution, or derivative modeling requires written permission from Assiut University.