Inhibition of human and marmoset 17β-HSD1 and 17β-HSD2 by compounds 1–20.
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aHuman placental, cytosolic fraction, substrate E1, 500 nM, cofactor NADH, 500 µM;bHuman placental, microsomal fraction, substrate E2, 500 nM, cofactor NAD+, 1500 µM;cLogit transformed values calculated from % inhibition at 50 nM inhibitor concentration, for inhibition values 70%, a trend is given;dMarmoset monkey placental, cytosolic fraction, substrate E1, 500 nM, cofactor NADH, 500 µM;eMarmoset monkey placental, microsomal fraction, substrate E2, 500 nM, cofactor NAD+, 1500 µM;fInhibitor concentration: 5 nM; n.i.: no inhibition; Human IC50 values were retrieved from literature (corresponding references are indicated with the structural formulas in Fig. 3).
创建时间：
2015-12-02
