The canonical function of the Hippo signaling pathway is the regulation of organ growth. How this pathway controls cell fate determination is less well understood. Here, we identify a function of the

NIAID Data Ecosystem60

Global microRNA expression analysis in HaCaT human keratinocytes transfected with siRNA(s) for p72, NF2/LATS2, DROSHA/DGCR8, or negative control. Homo sapiens

miRNA生物合成调控

Hippo信号通路

Global downregulation of microRNAs (miRNAs) is commonly observed in human cancers and can have a causative role in tumorigenesis. The mechanisms responsible for this phenomenon remain poorly understoo

NIAID Data Ecosystem50

Supplementary Material for: Altered Expression of Hippo Signaling Pathway Molecules in Intrahepatic Cholangiocarcinoma

Hippo信号通路

肝内胆管癌

Objective: MOB1, a core component of the Hippo signaling pathway, suppresses cell proliferation, and MOB1 liver conditional knockout mice develop intrahepatic cholangiocarcinoma (ICC). H

DataCite Commons2020-09-02 更新70

Interpretable deep learning reveals the sequence rules of Hippo signaling (ChIP-Seq). Interpretable deep learning reveals the sequence rules of Hippo signaling (ChIP-Seq)

Hippo信号通路

转录因子结合位点分析

How specific cells respond to signaling pathways is largely encoded in the DNA sequence. However, the sequence rules result from complex interactions between signaling and cell-type-specific transcrip

NIAID Data Ecosystem60

Knockdown of Yap1 and Wwtr1 in normal and fibrotic murine alveolar type II cells

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