Resistance to hop iso-_-acids in yeast involves active export and vacuolar sequestration

The hop plant, Humulus lupulus L., contains an exceptionally high content of secondary metabolites, the hop iso-_-acids, which possess a range of beneficial properties including antiseptic action啤酒花（Humulus lupulus L.）含有异常高含量的次生代谢产物（secondary metabolites），其中的啤酒花异-_-酸具备多种有益特性，包括抗菌作用。