Supplementary Material for: Holistic Treatment Incorporating Moist Wound Healing for Postoperative Radiation-Induced Perineal Ulcer in Rectal Malignancy: A Case Report

This article reports a case of extensive radiation-induced perineal ulcer in a 67-year-old male following postoperative radiotherapy for rectal cancer. One month after undergoing endoscopic submucosal dissection (ESD) and definitive radiotherapy for rectal carcinoma, the patient developed progressive perianal skin ulceration. Despite four weeks of conventional dry exposure therapy with saline irrigation at an external institution, the ulceration extended to involve the scrotum, penis, and bilateral inguinal regions. Following admission, a comprehensive treatment regimen based on moist wound healing principles was initiated, which resulted in complete re-epithelialization of the lesions within one week. This case report provides novel clinical insights into the management of radiation-induced cutaneous injury.