The altered substrates are shown with the amino acid(s) substitution(s) or truncations shown in bold. Reported values are the average kcat/KM values of 5–7 experiments. Uncertainty is expressed by sta
aConversion of NAD+ into cADPR, in percent of the reaction products, bcADPR was determined using the cycling assay, the other data were obtained using a radiometric HPLC assay with 14C-NAD+ as substra