Striatal gene expression profile of the YAC 128 mouse

The Yeast Artificial Chomosome (YAC) 128 model of Huntington's disease shows substantial deficits in motor, learning and memory tasks and alterations in its transcriptional profile. We examined the changes in the transcriptional profile in the YAC 128 mouse model of HD at 6, 12, and 18 weeks Brain striatal tissue from Wild Type and YAC 128 mice were sampled at the three age groups亨廷顿病（Huntington's disease, HD）酵母人工染色体（Yeast Artificial Chromosome, YAC）128型小鼠模型，在运动、学习与记忆相关任务中呈现显著功能缺损，且其转录组谱存在异常改变。本研究针对该亨廷顿病YAC 128小鼠模型，于6周、12周及18周三个时间点检测其转录组谱的变化，并在上述三个年龄组中，分别采集野生型（Wild Type）与YAC 128模型小鼠的大脑纹状体组织。