Hinch2004_VentricularMyocytes

This a model from the article:
A simplified local control model of calcium-induced calcium release in cardiac
ventricular myocytes.

Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. Biophys J
2004 Dec;87(6):3723-36 15465866
,
Abstract:

Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high
gain and is graded. These properties result from local control of Ca2+ release.
Existing local control models of Ca2+ release in which interactions between
L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs)
are simulated stochastically are able to reconstruct these properties, but only
at high computational cost. Here we present a general analytical approach for
deriving simplified models of local control of CICR, consisting of
low-dimensional systems of coupled ordinary differential equations, from these
more complex local control models in which LCC-RyR interactions are simulated
stochastically. The resulting model, referred to as the coupled LCC-RyR gating
model, successfully reproduces a range of experimental data, including L-Type
Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current
with and without Ca2+ release from the sarcoplasmic reticulum,
voltage-dependence of excitation-contraction coupling gain, graded release, and
the force-frequency relationship. The model does so with low computational cost.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004) - version02

The original CellML model was created by:
Terkildsen, Jonna,

[e-mail]
University of Auckland
Auckland Bioengineering Institute
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