Expression profiling of ncRNAs with custom microarray in 3, 10 and 20 month old wild type and 3xTG AD mice

In this study, we particularly focused on short ncRNA expression profiling of three, ten and twenty month old triple transgenic mouse model for Alzheimers disease (Oddo et al.; 2003;Neuron). These mice harbor presenilin PS1(M146V), APP(Swedish) and tau(P301L) mutations and develop beta-amyloid plaques and at later stages also a tau pathology. Controls are age matched B6129SF2/J mice.本研究着重针对3月龄、10月龄及20月龄的阿尔茨海默病三转基因小鼠模型（Oddo等，2003；《Neuron》）开展小非编码RNA（short ncRNA）表达谱分析。该类小鼠携带有早老素PS1(M146V)、APP（瑞典型）及tau(P301L)突变，可形成β-淀粉样蛋白斑块，并在病程后期出现tau蛋白病理改变。对照组为年龄匹配的B6129SF2/J小鼠。