Buddlejasaponin IVb alleviates DSS-induced ulcerative colitis through the Nrf2/GPX4 pathway and gut microbiota modulation

Buddlejasaponin IVb (BJP-IVb) is a triterpenoid saponin isolated from Pleurotus ostreatus, rich in bioactive components. However, its therapeutic effects and mechanisms against intestinal inflammation remain unclear. This study aimed to investigate the effects and mechanisms of BJP-IVb on colitis alleviation. A DSS-induced colitis mouse model was used to evaluate the impact of BJP-IVb on intestinal epithelial barrier function and gut microbiota regulation.