Selected predicted secondary targets of compound 1 in humans.

Human secondary targets are involved in metabolism; polynucleotide synthesis, repair, and replication; amino acid synthesis; blood clotting; vision; and nuclear transport. “AD score” refers to the AutoDock-predicted energy of binding to 1; “SOIPPA p-value” refers to the similarity between the secondary-target and TbREL1 active sites; “sequence identity” refers to the percent amino-acid identity with TbREL1 as computed by the CLUSTALW2 algorithm; and “FATCAT p-value” refers to the structural similarity between the secondary target and TbREL1. Protein sequences were extracted from PDB seqres headers.