Tracheal aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia

We analyzed mRNA profiles in tracheal aspirates from 53 newborns receiving invasive mechanical ventilation. Twenty-six infants were extremely preterm diagnosed with BPD and twenty-seven were term babies receiving invasive mechanical ventilation for elective procedure. Specific mRNA signatures in TAs may serve as potential biomarkers for extreme prematurity and BPD pathogenesis. We extracted RNA from 0.5 mL of tracheal aspirates from neonates without lung disease or with bronchopulmonary dysplasia. Transcriptomic analysis was performed by RNAseq. Raw data is not provided due to the agreement by Institutional Review Board (IRB).