Prime editing: targeted sequencing
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP307854
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资源简介：
Although prime editing can introduce any small-sized genetic change, the efficiency of prime editor 2 (PE2) is often insufficient, limiting its applications. Here we generated a variant of PE2, named hyPE2, by adding the Rad51 DNA-binding domain between the Cas9 nickase and reverse transcriptase domains. Editing efficiencies of hyPE2 were up to an average of 2.5-fold higher than those of PE2 in cultured human cells, potentially facilitating prime editing applications
创建时间：
2021-07-01
