GEMiCCL

Cancer cell lines are essential components for biomedical research. However, proper choice of cell lines for experimental purposes is often difficult because genotype and/or expression data are missing or scattered in diverse resources. GEMiCCL (Gene Expression and Mutations in Cancer Cell Lines) is an online database of human cancer cell lines that provides genotype and expression information. The mutation, gene expression, and copy number variation (CNV) data were collected from three representative databases on cell lines – CCLE (Cancer Cell Line Encyclopedia), COSMIC (Catalogue of Somatic Mutations in Cancer), and NCI60. We re-processed the entire gene expression and SNP chip data and removed the batch effects due to different microarray platforms using the ComBat software.癌细胞系是生物医学研究的关键组成部分。然而，实验研究中合理遴选细胞系往往颇具挑战，原因在于基因型及/或表达数据存在缺失，且分散于各类异构数据源中。GEMiCCL（Gene Expression and Mutations in Cancer Cell Lines）是一款面向人类癌细胞系的在线数据库，可提供基因型与表达谱相关信息。该库涵盖的突变、基因表达与拷贝数变异（CNV, Copy Number Variation）数据，均取自三类代表性细胞系数据库——CCLE（Cancer Cell Line Encyclopedia）、COSMIC（Catalogue of Somatic Mutations in Cancer）以及NCI60。我们对全部基因表达数据与单核苷酸多态性芯片数据进行了重新处理，并通过ComBat软件消除了不同微阵列平台所带来的批次效应。

搜集汇总

背景与挑战

背景概述

GEMiCCL是一个人类癌症细胞系在线数据库，整合了来自CCLE、COSMIC和NCI60的突变、基因表达和拷贝数变异数据，并重新处理以消除平台批次效应。该数据库涵盖大量细胞线，提供标准化临床信息，并支持搜索、浏览及交互式可视化功能。