Integrated lncRNAs and mRNAs sequencing reveals lncRNAs regulatory network associated with lung injury in LPS-induced septic shock rats

Sepsis is associated with increased morbidity and mortality. Long non-coding RNAs (lncRNAs) have been associated with human diseases. Here, we used a microarray to analyze lncRNAs and mRNAs expression and functional network of lung injury in lipopolysaccharide (LPS)-induced septic shock rats.脓毒症与更高的发病率和死亡率显著相关。长链非编码RNA（long non-coding RNAs，lncRNAs）已被证实与人类多种疾病存在关联。本研究采用基因芯片技术，对脂多糖（lipopolysaccharide，LPS）诱导的脓毒性休克大鼠肺损伤模型中长链非编码RNA及信使RNA（mRNA）的表达谱及其功能调控网络进行了分析。