Secondary optimization can reduce the optimal solution space to a unique flux distribution.
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For the E.coli iAF1260 genome-scale model, secondary optimization reduced the optimal solution space from 1–120 million vertices to about 1–432 vertices. When we minimize pathway cost (Pc) a unique optimal flux distribution exists, but many suboptimal flux distributions do exist (Fig. 5).Secondary optimization can reduce the optimal solution space to a unique flux distribution.
创建时间：
2015-12-03
