We performed deep mutational scanning of human angiotensin-converting enzyme 2 (ACE2) to evaluate how mutations affect recognition by the SARS-CoV-2 spike protein.
TnT cells reconstituted with DMS libraries and displaying restored TCR-CD3 surface expression were isolated by FACS, expanded and re-sorted based on binding to cognate peptide-MHC dextramer or activat
This record contains supplementary data files related to Deep mutational scanning to characterize the mechanistic role of TYK2 in immune signaling and disease, described below. - tyk2.bcmap-final.