Transcriptomic analysis of dynamic dysregulation in brainstem autonomic nuclei during the development of hypertension

Neurogenic hypertension stems from an imbalance in autonomic function that shifts the central cardiovascular control circuits towards a state of dysfunction. Using the female spontaneously hypertensive rat (SHR) and the normotensive Wistar Kyoto (WKY) rat model, we compared the transcriptomic changes in three autonomic nuclei in the brainstem, the nucleus of the solitary tract (NTS), caudal ventrolateral medulla (CVLM), and rostral ventrolateral medulla (RVLM) in a time series at 8, 10, 12, 16, and 24 weeks of age, spanning the pre-hypertensive stage through extended chronic hypertension.神经源性高血压（Neurogenic hypertension）由自主神经功能失衡引发，致使中枢心血管控制环路陷入功能失调状态。本研究以雌性自发性高血压大鼠（spontaneously hypertensive rat, SHR）与血压正常的Wistar Kyoto（WKY）大鼠为实验模型，针对脑干内三个自主神经核团——孤束核（nucleus of the solitary tract, NTS）、尾侧腹外侧延髓（caudal ventrolateral medulla, CVLM）以及头端腹外侧延髓（rostral ventrolateral medulla, RVLM）——开展了时序转录组学比较分析，采样年龄涵盖8、10、12、16及24周龄，覆盖了从高血压前期至慢性高血压持续进展的全病程阶段。