Interdental plaque microbiota treated with NO

The deterioration of human oral microbiota is known not only to cause oral diseases but also to affect systemic health. Various environmental factors are thought to influence the disruption and restoration of oral ecosystem. In this study, we focused on the effect of nitric oxide (NO) produced by denitrification and immune cells on plaque flora. Interdental plaques collected from 10 subjects were exposed with NO donor sodium nitroprusside (SNP), and cultured in SHI medium. This study has provided an overview of how oral plaque microbiota shifts with exposure to NO and may contribute to the development of a method for adjusting the balance of the oral microbiome.