(a and b) Direct comparison of recombination events at centromeres and telomeres per kilobase relative to global SCE events in kilobase () in wild-type and -deficient ES cells

Note that centromeres are sixfold more recombinogenic than telomeres. The T-SCE/SCE and C-SCE/SCE ratios also indicate that both telomeres and centromeres are more recombinogenic than the global genome. C-SCE and T-SCE, but not SCE (see ), are further increased in the absence of Dnmts. Statistical significance comparisons with the respective wild-type value are indicated on top of each bar.<b>Copyright information:</b>Taken from "Centromere mitotic recombination in mammalian cells"The Journal of Cell Biology 2008;181(6):885-892.Published online 16 Jun 2008PMCID:PMC2426939.