Pien-Tze-Huang Promotes Hepatocellular Carcinoma Cell Ferroptosis by Inhibiting SLC7A11-GSH-GPX4 Axis

We aimed to evaluate anti-cancer efficacy of Pien-Tze-Huang (PZH), and to investigate the underlying mechanisms by integrating transcriptional regulatory network analysis and experimental validation. Overall design: After detecting a transcriptomic profiling, the “disease-related gene--drug effective target” interaction network was constructed, and the candidate targets of PZH against malignant transformation from liver fibrosis to HCC were identified and verified in vitro.