Expression data from edema toxin treated primary hepatocytes from 1–3-day-old neonatal A/J mice

The activity of known anthrax toxins is insufficient to account the effects on functions of hepatocytes. In vivo and in vitro studies showed that Anthrax edema toxin (EdTx) induce lethal liver and heart damage We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated and down-regulated genes during this process. Primary hepatocytes were selected from 1–3-day-old neonatal A/J miceat for RNA extraction and hybridization on Affymetrix microarrays. To investigate the mechanism underlying the toxicity of EdTx for hepatocytes, we conducted a microarray assay to identify potential genes related to impaired liver function induced by EdTx treatment.