Oligonucleotide Phosphorothioates Enter Cells by Thiol-Mediated Uptake
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DiI-labeled and calcein encapsulated Control-lipo (EPC/DOPE/CHEMS) (a), LMDP-lipo (EPC/DOPE/CHEMS/5 mol% LMDP) (b), LMDP-lipo in the presence of 50 µM DAPT (c), LMDP-lipo in the presence of 0.4 M sucr
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Table_1_Current Development of siRNA Bioconjugates: From Research to the Clinic.pdf
Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation. The main problems in the development of
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The mechanism of internalization study of QDgreen−CD−FA−C−2028 conjugate at IC80 value to cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells
The influence of different endocytosis inhibitors on the internalization of QDgreen−CD−FA−C−2028 conjugate at IC80 value in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells. First,
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Optimization of a cationic liposomal gene delivery system and study of its endocytic pathway
Abstract A cationic liposomal gene delivery system comprising DOTAP, DOPE, and cholesterol was prepared and optimized. The results showed that the liposome/DNA (LP/DNA) system had spherical morphology
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DNA Barcoding reads from in vivo mouse delivery. Mus musculus breed:BALB/c
DNA barcoding is a powerful technology that can be used to rapidly test efficiency of delivery of many different delivery vehicles, such as LNPs, at the same time. However, DNA barcodes are small olig
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