Phosphorylation of E proteins by p38 MAPK

p38 MAPK plays a fundamental role in the transition of myoblasts to different myocytes. Activated p38 MAPK phosphorylates E12/E47, a member of the E protein subfamily of bHLH proteins. p38 MAPK in particular phosphorylates Ser140 of E47. Its been observed that phosphorylation of E47 improves its ability to form heterodimers with Myod transcription factor.

p38 MAPK 在肌原细胞的分化过程中扮演着至关重要的角色。激活的p38 MAPK对E12/E47进行磷酸化，E12/E47属于bHLH蛋白的E蛋白亚家族。特别是p38 MAPK对E47的Ser140位点进行磷酸化。研究表明，E47的磷酸化提高了其与Myod转录因子的异源二聚体形成能力。