Crystal structure of AICARFT bound to an antifolate
收藏Protein Data Bank Japan2024-03-06 更新2026-03-21 收录
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Crystal structure of AICARFT bound to an antifolate Descriptor: 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, ... Authors: Wang, J, Wang, Y, Fales, K.R, Atwell, S, Clawson, D. Deposit date: 2017-02-23 Release date: 2018-01-10 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60, 2017
创建时间：
2017-02-23
